2:30pm Unlocking the Potential: ADC Cutting Edge Analytical Development Strategies
Time: 2:30 pm
day: Day One CMC Track
Details:
- • Mass spectrometry (MS) offers high selectivity and specificity for the comprehensive structural characterization of antibodies and ADCs
- Among the MS-tool box, advantages of native and Ion Mobility MS, Collision Induced Unfolding (CIU) and Cyclic CIU, multiplexed Top and Middle-Down MS, multiple fragmentation techniques and Capillary Electrophoresis hyphenated to MS (CE-MS) will be discussed
- Multiple Attributes Method (MAM) based on High Resolution MS data for identification and quantitation of Critical Quality Attributes (CQAs) in one single analysis for mAbs and ADCs
