Leveraging Multiple Mechanisms of Action to Improve the Therapeutic Index of ADCs

Time: 9:40 am
day: Day Two


  • Addressing the tumor delivery challenges and payload toxicity limiting the therapeutic index (TI) of ADCs
  • Understanding how antibody optimization, in addition to the linker/payload, can improve delivery and MoA
  • Exploring counter-intuitive strategies, guided by quantitative pharmacology, that can increase the TI of ADCs