Leveraging Multiple Mechanisms of Action to Improve the Therapeutic Index of ADCs

Time: 9:40 am

Details:

• Addressing the tumor delivery challenges and payload toxicity limiting the therapeutic index (TI) of ADCs
• Understanding how antibody optimization, in addition to the linker/payload, can improve delivery and MoA
• Exploring counter-intuitive strategies, guided by quantitative pharmacology, that can increase the TI of ADCs