Developing High-Efficacy, Stable Drug Bundle-Based ADCs with Optimized Dual Payload Combinations
Time: 3:30 pm
day: Scientific Program Day Two PM
Details:
- Dual Drug Bundles: Optimized dual-payload combinations are designed to enhance therapeutic efficacy and overcome resistance
- CHO-TEM ADC Technology: A one-step enzymatic process and mild conjugation conditions modify antibody glycans to introduce four azido groups, allowing the conjugation of four drug bundles—each containing two drugs from distinct categories
- High-Efficacy and Stable ADCs: Glycosite-specific conjugation of drug bundles enables the development of high-DAR ADCs with dual payloads, ensuring both efficacy and stability
