2:30pm Roundtable Discussion: Stable Versus Unstable Linkers for Optimizing Clinical Performance of ADCs

Time: 2:30 pm
day: Day Two Preclinical & Clinical Development Track

Details:

• Exploring the pros and cons of linker stability in ADC efficacy and toxicity
• Evaluating how stable linkers may prevent deconjugation, while unstable linkers can offer quicker payload release and enhance the bystander effect
• Discussing the balance between stability and controlled cleavage for optimized therapeutic outcomes