Workshops

Pre-Conference Workshop Day

Workshop A: Advanced Design of ADCs: Principles & Applications with Next Generation Linkers & Site Specific Technology


Workshop Leader:

   Rick Powers
   Independent Consultant

 

Let’s explore various ways to improve the therapeutic window of ADCs using a rational approach to improve clinical performance by building a better molecule. By incorporating improvements in solubility as well as attachment stability, great strides can be made.

Join this workshop to discuss various methods for obtaining a defined DAR, and the pros and cons of several key approaches. Particular attention will be given to dual and multiwarhead ADCs, and the various ways to achieve controlled multivalency on native and engineered proteins. Lastly, with the emergence of Immuno-oncology, dual binding bi-specific antibodies will be discussed as a platform for ADC conjugations.

Workshop B: Improving Understanding of Combination Approaches & Exploring How Combinations Can be Used to Enhance the Therapeutic Window of ADCs

 

Workshop Leader:

   Greg Thurber
   Associate Professor
   University of Michigan

 

  • Understanding the rationale for combination studies – potential mechanisms of synergy
  • Current state-of-the-art – assess results from combination clinical trials
  • Exploring rational approaches to combination trials
  • Looking to the future, where do we see combinations going and how do we need to adapt our processes

Workshop C: Part 1: Introduction to Discovery & Design of Novel ADCs

 

Workshop Leader:

    John Lambert
    Executive Vice President, Emeritus & Distinguished Fellow
    Immunogen

 

This workshop will offer a one-day intense learning environment to establish core skills and understanding in the critical areas of ADC research and development. Designed for new entrants to the ADC field it will deliver critical knowledge in a number of the key problem areas that hinder antibody-drug conjugate programs.

Covering essential elements in ADC discovery and early development, this workshop will enable you to:

  • Gain an overview of the development process for ADCs
  • Improve payload and linker design chemistry
  • Understand the impact of conjugation site selection on your ADC
  • Choose/choice of optimum “antibody” format

 

Workshop C Part 2: Introduction to Discovery & Design of Novel ADCs

 

Workshop Leader:

    John Lambert
    Executive Vice President, Emeritus & Distinguished Fellow
    Immunogen

 

Following on from part 1 the second half of the workshop will cover and will enable you to:

  • Select the most appropriate ADC target which is easily accessible
  • Learn about cellular assays
  • Review the advantages and disadvantages of different preclinical animal models
  • Develop early stage essays and learn how to effectively interpret the data